An engineered viral protein enhanced the anticancer function of T cells in mice, suggesting a new strategy to improve ...

A pair of recent studies from the laboratory of Bin Zhang, MD, Ph.D., the Johanna Dobe Professor of Cancer Immunology, have ...

A new study found that taurine, an amino acid often added to energy drinks, may fuel the growth of leukemia cells. But can ...

Like much of Dr. Xue’s other work, the latest paper focuses on CD8+ T cells ... these effector cells eventually enter a state of Exhaustion” which makes them less and less effective.

Their study demonstrated that prolonged antigen stimulation in vitro caused upregulation of key exhaustion markers—PD-1, LAG-3, TIM-3, TIGIT, and CD39—on both CD4+ and CD8+ T cells. These markers were ...

it is an important transcription factor that regulates CD8+ T cell activation and exhaustion. The current study explored the roles of ACSS2 and ACLY in TEX cell formation during chronic LCMV ...

“When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8+ T cells,” Grimson said. Meanwhile, in Hanson’s lab, ...

If CD8+ T cell exhaustion can be reversed, the next question is whether such reversal actually benefits a patient, as exhaustion can have protective qualities.

"When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8 + T cells," Grimson said. Meanwhile, in Hanson's lab ...