it is an important transcription factor that regulates CD8+ T cell activation and exhaustion. The current study explored the roles of ACSS2 and ACLY in TEX cell formation during chronic LCMV ...

“When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8+ T cells,” Grimson said. Meanwhile, in Hanson’s lab, ...

If CD8+ T cell exhaustion can be reversed, the next question is whether such reversal actually benefits a patient, as exhaustion can have protective qualities.

"When we looked at all of the differences [compared to normal functioning], they really pointed us towards an exhaustion-like state for the CD8 + T cells," Grimson said. Meanwhile, in Hanson's lab ...

Like much of Dr. Xue's other work, the latest paper focuses on CD8 + T cells ... these effector cells eventually enter a state of "exhaustion" which makes them less and less effective.

This altered metabolism resulted in increased levels of lipid peroxides and potentiated the metabolic and functional exhaustion of CD8 + T cells in cancer. Chronic type I interferon signaling ...

Silencing KLF2 drove the CD8 T cells along a different path, directing them away from becoming killer cells and toward a ...

Cannabis and its synthetic cannabinoids have been studied for medicinal properties across multiple d Researchers evaluated the effect of cannabis on inflammation, immune function, and the HIV ...

“T cell exhaustion is a specific CD8 + T cell differentiation state that is induced by chronic exposure to antigen such as from chronic viral infections or cancer,” the investigators wrot ...