However, knowledge of a more active role of mast cells has emerged, largely owing to observations in patients with disorders that involve clonal expansion of mast cells in the bone marrow.

A rare set of immune diseases called clonal mast cell activation disorders (cMCADs) may be associated with strong immunity to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2 ...

If the person meets the criteria for a diagnosis of MCAS, a doctor needs to rule out a primary clonal mast cell disorder as the cause. This requires further blood testing for a mutation called KIT ...

Within the group of 12 patients who had idiopathic anaphylaxis, five were found with evidence of a disorder in a line of mast cells (clonal mast cell disorder). The researchers looked for evidence ...

Kounis syndrome is a ubiquitous disease affecting individuals of any ... We had previously suggested that a threshold level of mast cell content (tryptase, chymase and so on) exists [15] above ...

Studies on mastocytosis revealed a subgroup of patients presenting symptoms of increased MC degranulation, defined as mast cell activation syndrome (MCAS). This population includes patients with ...

can trigger an extensive work-up for clonal mast cell disease, including bone marrow biopsy. Because elevated tryptase levels are seen in a relatively large proportion of the general population ...

“The designation is the highest bestowed by AIM and requires meeting many stringent criteria, including expertise in multiple medical specialties serving mast cell disorders and mastocytosis ... by an ...

The authors discuss the role of mast cells in pregnancy in both healthy and disease states in a review article published in May. [3] Mast cells participate in "implantation, placentation ...

Mast cell activation syndrome (MCAS) is a condition that occurs when the mast cells in your body release too much of a substance that causes allergy-like symptoms. Mast cells are part of your ...