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The winning numbers from the Wednesday, May 21 drawing are 9, 29, 31, 34 and 43. The Powerball was 2 . The Power Play multiplier was 2x. Check back to see if anyone won the Powerball jackpot.

Here are Wednesday’s winning lottery numbers: The estimated Powerball jackpot is $146 million. The lump sum payment before taxes would be about $65.6 million.

The Powerball jackpot rose to $146 million ahead of Wednesday's drawing. Check here for the winning numbers for May 21, 2025.

Winning Powerball numbers and lottery results for $146 million drawing jackpot Wednesday, May 21, 2025. Did anyone win last night? When is the next drawing?