Lymphomas belong to the group of malignant diseases of the immune system and mainly affect the organs of the lymphatic system. Anaplastic large cell lymphoma (ALCL) belongs to the subgroup of ...

Lymphomas belong to the group of malignant diseases of the immune system and mainly affect the organs of the lymphatic system ...

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Molecular biology has transitioned to a new era where precise genetic manipulation plays a critical role in research, medicine, and biotechnology. Among the vital tools in this field are cloning ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding ...

Genetic knockdown of DHX9 results in strong reduction of proliferation and survival in CRC cells characterized as MSI-H/dMMR, but not in microsatellite stable (MSS) CRC cells with proficient MMR (pMMR ...

Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, China Introduction: Prior cohort studies reported paradoxical results between proton pump inhibitor (PPI ...

Interest in developing selective inhibitors has produced tool compounds for the inactivation or degradation of AKR1C3 with varying degrees of selectivity among the 14 known AKR proteins. Selectivity ...

Although ALP alterations in the Q175 model are milder and later onset compared to human HD, they do show lysosome depletion and impaired autophagic flux. Treatment with an mTOR inhibitor in ...

Identification of inclusions and HTT molecular species in Q175 mice. (A) IHC detects age-dependent increase in the number of mHTT inclusions. Brain sections from 6-mo- and 10-mo-old WT and Q175 mice ...