The condition occurs due to issues with the enzyme known as hypoxanthine-guanine phosphoribosyltransferase (HPRT), which results in the accumulation of uric acid. Lesch-Nyhan syndrome is an X ...

Lesch-Nyhan syndrome is a rare X-linked genetic disorder caused by a deficiency in the enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). This enzyme is involved in purine salvage, and its ...