The proposed transition state for hypoxanthine-guanine phosphoribosyltransferases (HGPRTs) has been used to design and synthesize powerful inhibitors that contain features of the transition state.

With a new wave of serums claiming to extend our skin cells' lifespan, can these products help us better understand what lies beneath the surface – or is this simply ‘anti-ageing’ 2.0?

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Visfatin could act as a nicotinamide phosphoribosyltransferase and biosynthesize NMN (nicotinamide mononucleotide) which mediated a proliferative response in VSMC via ERK and p38 MAPK signaling ...

aDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Department of Medicine, University of Toronto, Toronto, ON, Canada The identification of molecular targets and the ...

Here, for the first time, we employ a multiscale and hybrid quantum mechanical–molecular mechanical simulation to study the interaction of OH radicals with a guanine-deoxyribose-phosphate DNA ...

Obstructive sleep apnea (OSA) has been associated with oxidative stress and various cardiovascular consequences, such as increased cardiovascular disease risk. Quantitative real-time PCR is frequently ...

A new natural product oxazoline derivative named aeglemarmelosine (1) along with eight known compounds (2-9) were isolated from roots and twigs of Aegle marmelos. Compounds 1-6 were isolated from the ...