Conclusions—These results indicate that P-selectin interaction with a ligand, different from PSGL-1 or GP Ib, stabilizes initial GP IIb/IIIa–fibrinogen interactions, allowing the formation of large ...

This shear-induced platelet aggregation (SIPA) is mediated by von Willebrand factor binding to platelet membrane glycoprotein (GP) Ib and GPIIb/IIIa. The chimeric Fab fragment of the monoclonal ...

Cardiovasc Rev Rep. 2004;25(6) © 2004 Le Jacq Communications, Inc. Cite this: Bleeding Due to Glycoprotein IIb/IIIa Receptor Inhibition During Percutaneous Coronary ...

[13,14,15] In addition, thrombin binds to protease-activated receptors on platelets, ultimately resulting in upregulation of glycoprotein Ib/IX (GPIb/IX) and glycoprotein IIb/IIIa (GPIIb/IIIa ...

Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing dodecapeptide ...