The structures of the Fc regions of human IgG, IgE and IgA have been solved, revealing similarities in overall domain arrangements. The extracellular domains of the human IgG Fc receptors FcγRIIa ...

Concentration-dependent cleavage of IgE B cell receptor. Concentration-dependent reduction of expression of the high-affinity IgE Fc receptor, on bone marrow-derived mast cells from humanized mice.

A breach in the gut immunity and crossreactivity of the IgE antibodies with skin antigens or direct interaction with specific IgE, Fc receptors on Langerhans cells, mast cells, monocytes ...

Although IgE actually contains 2 copies of its Fc-epsilon-RI and Fc-epsilon-RII binding sites, [19, 34] omalizumab does not bind to the second site of an IgE antibody that is already bound to Fc ...

An Fc receptor can specifically bind to the Fc region of the immunoglobulins. Currently, FcRn and FcRare the two most common tested Fc receptors.

MOv18 IgE is Epsilogen’s lead IgE antibody drug candidate and binds to anti-folate receptor (FRα), a well validated target for ovarian cancer.

Turning to neonatal Fc receptors, Wright noted that these therapies are not targeting cytokines, but the “recycling” that occurs to prevent degradation of IgG.

Epsilogen licences MOv18 IgE, an anti-folate receptor alpha IgE antibody from King's College London MOv18 IgE is currently in phase 1 clinical trial in cancer patients with advanced solid tumours ...

Anti-IgE antibodies block the IgE-Fc receptor interaction and prevent subsequent allergic symptoms.

Immunoglobulin E (IgE) and the high affinity IgE receptor (FcεRI) have been suggested to contribute to the pathogenesis of autoimmune disorders. Their role in Wegener’s granulomatosis (WG) are, ...

Immunoglobulin G Fc Receptor FcγRIIIa 158 V/F Polymorphism Correlates With Rituximab-Induced Neutropenia After Autologous Transplantation in Patients With Non-Hodgkin's Lymphoma ...