John Mascarenhas, MD, discusses the rationale, mechanism, and design of the phase 1 INCA33989-101 and -102 trials investigating a CAL-R–targeted antibody for patients with essential thrombocythemia.

The H 1 receptor appears to play a predominant role in IgE-mediated allergic conditions because perturbation of this receptor leads to tissue responses and symptoms of allergic rhinitis and urticaria.

Galectin-1 seems to bridge innate and adaptive immunity in part by regulating the Fc receptor- and MHC-dependent immune functions of monocytes and macrophages through an extracellular-signal ...

IgE antibodies mainly bind to the high-affinity IgE receptor (FcεRI) and to the low-affinity IgE receptor (FcεRII/CD23). Moreover, the IgE-binding protein galectin-3 has been shown to cross-link ...