Activation of the high-affinity Fc receptor for IgE (FcɛRI) on mast cells results in increased activity of SPHK1 and SPHK2, the formation of intracellular S1P and its export into the ...

Neonatal Fc Receptor (FcRn): A receptor that binds IgG at acidic pH, protecting it from lysosomal degradation and extending its circulating half-life.

John Mascarenhas, MD, discusses the rationale, mechanism, and design of the phase 1 INCA33989-101 and -102 trials investigating a CAL-R–targeted antibody for patients with essential thrombocythemia.

Sidebar Executive Summary. IgE-mediated hypersensitivity is characterized by an overboarding Th2 response affecting up to 25% of the population in industrialized countries.

The H 1 receptor appears to play a predominant role in IgE-mediated allergic conditions because perturbation of this receptor leads to tissue responses and symptoms of allergic rhinitis and urticaria.

IgE antibodies mainly bind to the high-affinity IgE receptor (FcεRI) and to the low-affinity IgE receptor (FcεRII/CD23). Moreover, the IgE-binding protein galectin-3 has been shown to cross-link ...

Studies have shown that high antibody titers in patients with COVID-19 are associated with disease severity and increased mortality. 105,106 Relevant to the increased antibody titer in human platelets ...