The aim of this study was to identify patterns of atrophy that would not only differentiate these primary neurodegenerative pathology groups from cognitively healthy control subjects but, critically, ...

Objective Spinal muscular atrophy (SMA) is a neuromuscular disorder that manifests with motor deterioration and respiratory complications. The paradigm of care is shifting as disease-modifying ...

Compared with placebo, ATH434 demonstrated a statistically significant 48% slowing of clinical progression (based on UMSARS score) at the 50mg dose at week 52. The Food and Drug Administration ...

Geographic atrophy is diagnosed with a dilated eye exam and imaging testing such as retinal fundus photography (a color image of the retina) or autofluorescence imaging (which shows where geographic ...

Alterity’s previous interactions with the FDA indicated that the modified Unified Multiple System Atrophy Rating Scale (UMSARS) Part I scale is considered a clinically meaningful endpoint for MSA.

Geographic atrophy (GA) is an advanced stage of age-related macular degeneration (AMD) that can lead to vision loss as retina cells die. It affects about 1 million people in the United States. Studies ...

(0:54) How does one time surgery for scoliosis in children with pediatric spinal muscular atrophy get a maximum benefit without impeding growth? Dr. Ashley E. Webb of the University of Texas ...

Jokes by comedian Samay Raina - that allegedly mock visually impaired and a baby suffering from spinal muscular atrophy, and requiring a Rs 16 lakh injection to survive - have been flagged by the ...

Background: Determining brain atrophy is crucial for the diagnosis of neurodegenerative diseases. Despite detailed brain atrophy assessments using three-dimensional (3D) T1-weighted magnetic resonance ...

However, our knowledge is still lacking about the trajectories of the hippocampus and hippocampal subfields atrophy with the progression of Alzheimer’s disease. Objective: To identify which subfields ...