Scientists have discovered a powerful anticancer compound hidden within a toxic fungus historically linked to the mysterious ...

Rab GTPases: Small GTP-binding proteins that regulate vesicle trafficking by cycling between active and inactive states. ... Rab GTPase Function in Endosome and Lysosome Biogenesis.

We also observed that the lysosomes in cells treated with tunicamycin and BADG were more sensitive to SiO 2 than those in untreated control cells (Fig. 7 E and F). Taken together, these data indicated ...

Intraluminal vesicles (ILVs) within MVBs are either directed toward lysosomal degradation or secreted as exosomes when MVBs fuse with the plasma membrane. This process is tightly regulated and has ...

The discovery of an unknown organelle inside our cells could open the door to new treatments for devastating inherited ...

Lysosomes are subcellular organelles that are mainly responsible for degradation of proteins internalized by cells by endocytosis and phagocytosis. Upon uptake, proteins and soluble components ...

The mechanisms of vesicle recycling at high stimulation frequency. In their publication, the researchers shed new light on the vesicle recycling process in hippocampal synapses. With their model, they ...

MSD has agreed to pay up to $610 million to acquire Caraway Therapeutics, a Cambridge, Massachusetts biotech focusing on neurodegenerative disorders and rare diseases.

People with lysosomal storage disorders lack important enzymes (proteins that speed up reactions in the body). Without those enzymes, the lysosome isn't able to break down these substances. When ...

Extracellular vesicles (EVs) have garnered significant attention in the biomedical field due to their potential applications. However, their small size and high heterogeneity pose challenges for ...

Endolysosomal vesicles form a highly dynamic multifunctional cellular compartment that contains multiple highly potent proteolytic enzymes. Originally these proteases have been assigned to cooperate ...