A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of ...

A recent study involving researchers from the University of Basel reveals that slowing down the intracellular transport of ...

That’s called a vesicle, or more precisely, a phagosome. Then the phagosome fuses with a lysosome to form a phagolysosome. Inside, digestive enzymes from the lysosome help destroy the germ.

However, some proteins can bypass this system using unconventional mechanisms, including direct translocation across the plasma membrane, transporter-mediated secretion, and intracellular vesicle ...

This interplay between CMA-driven protein targeting and macroautophagy-mediated vesicle dynamics provides a novel mechanistic framework for the unconventional secretion of PARK7. ” Their research ...

The proteins are clustered in one vesicle and then another vesicle and then finally handed off to the lysosome. We think NU-9 targets something in the early stage of that relay, but we don't know ...

Abstract Membranes undergo various patterns of deformation during vesicle fusion, but how this membrane deformation is regulated and contributes to fusion remains unknown. In this study, we developed ...

In cells, structures called lysosomes act as recycling centers that can digest different kinds of molecular material. Using microscopes at the SickKids Imaging Facility, Akriti Prashar, PhD, a ...

In immature oocytes at the germinal vesicle (GV) stage (grey, left), endosomes (white) and lysosomes (blue) assemble in large spherical structures called ELYSAs. The formation of an ELYSA prevents … ...

Lysosomes are spherical vesicles surrounded by a single membrane. This membrane helps to maintain an acidic pH inside the lysosome, which is essential for the activity of its hydrolytic enzymes.

Co-localization analysis and continuous imaging with super-resolution microscopy revealed that HPO-27 and MROH1 are recruited to lysosomes by RAB7 and regulate lysosomal membrane fission. Through ...