Gum disease caused by the bacteria Porphyromonas gingivalis is linked to worse multiple sclerosis (MS) in a mouse model of ...

Nanoparticle-driven spleen remodeling allowed transplanted ... In mice, nanoparticle treatment expanded regulatory T cells and M2 macrophages while reducing effector T cells and pro-inflammatory ...

the macrophages showed a reduced ability to surround and absorb other bacteria, a critical process called phagocytosis. Microplastic particles were readily detected in the liver, spleen and colon ...

In fact, Salmonella often infects macrophages in the spleen, which degrade old or damaged red blood cells. Since red blood cells contain large amounts of iron, the sites of their degradation are p ...

Using lineage tracing, we find that tissue-resident red pulp macrophages (RPM), initially depleted by BCG ... trained monocytes from the BM and diverse MP populations within the spleen, the temporal ...

The spleen is a key component of the immune system. It filters old blood cells, bacteria, tumor cells out of the blood and breaks them down. The macrophages then get rid of them. Historian Allan ...

In the red pulp of the human spleen, senescent and altered red blood cells (RBCs) undergo prefiltration, filtration, and postfiltration. Previous research has shown how macrophages detect and engulf ...

Department of Physiology and Hypoxic Biomedicine, Institute of Special Environmental Medicine and Co-innovation Center of Neuroregeneration, Nantong University, 9 Seyuan Road, Chongchuan District, ...

Any red blood cells that can’t pass through these tiny openings, because they’re damaged, stiffened or misshapen, become trapped and are destroyed by immune cells called macrophages. To model the ...

Within the spleen, blood flows through tissue known ... and the M chip, which mimics the macrophages. The device also includes a gas channel that can be used to control the oxygen concentration ...

This allowed macrophages to more easily digest them and clear up the clogged filters. The researchers are now using the spleen-on-a-chip to study how drugs used to treat sickle cell disease ...