In BG3, you can use the Gale Netherese Orb during Act 2 or Act 3 to get a secret or a different ending, respectively.

Partway through his questline, Gale gains the option to use the powerful Netherese Orb at some points in the story - but is using it worth the cost?

The Wrath of Netheril When the Netherese first established the Xin'kar Enclave, the wilderness was a dangerous distraction to their research.