“Whether or not they're better or worse than the ones that are conserved across species is a separate question, but I think this does open up a new ability to explore human oligodendrocyte development ...

Dr. Pablo M. Paez is a Principal Investigator of the Institute for Myelin and Glia Exploration and Assistant Professor in Pharmacology and Toxicology in the Jacobs School of Medicine and Biomedical ...

Although neural cell competition is widely recognized for its role during early brain development ... For example, in the ...

Projects work toward the development of novel drug and cell therapy for the ... are responsible for the production of the axon insulating sheath known as myelin. Oligodendrocyte progenitors are very ...

These studies support the development of LINGO1 antagonists ... It is conceivable that inhibiting LINGO1 causes oligodendrocyte precursor cells to differentiate into mature, myelin–forming ...

Taken together, these studies strongly indicate that the oligodendroglial NMDA receptor represents an important new pharmacological target in the development of treatments for demyelinating brain ...