The striatum contains the densest expression of dopamine receptors in the vertebrate brain ... On the other hand, if phasic variations in dopamine act as a signal to initiate movement, S41 S42 then ...

Yet, despite more than 20 years of study, the sweet receptor’s precise architecture remained elusive, even as scientists ...

Drugs that bind to and activate the receptors for the hormones GLP-1 and GIP are effective in the treatment of obesity and ...

Pfizer Inc. (NYSE: PFE) today announced the decision to discontinue development of danuglipron (PF-06882961), an oral glucagon-like peptide-1 (GLP-1) receptor agonist, which was being investigated ...

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs ... for heart health and kidney function in people with diabetes. For example, research has shown that treatment with Ozempic, Trulicity ...

To provide a clinical example, the presence of a positive ‘culture’ of PT in jumping sports, such as volleyball where playing with tendon pain is common (and may reinforce a concept that pain during ...

Genetically identical neurons that form Meissner corpuscles for picking up vibrations in glabrous skin, for example, also form lanceolate endings for detecting hair movement in hairy skin. In a 2023 ...

The effects that result depend on where the receptor is located and which endocannabinoid it binds to. For example, endocannabinoids might target CB1 receptors in a spinal nerve to relieve pain.

Glucagon-like peptide-1 receptor agonists (GLP-1RAs), currently licensed for the treatment of type 2 diabetes mellitus and obesity, offer a novel, multilayered mechanism for intervention in ...

A combination of methods, including a new method for tagging genes, demonstrates that the chemosensory co-receptors of Drosophila melanogaster (Orco, IR8a, IR25a, IR76b) are expressed widely and ...

For example, one mouse completed only 10 rewarded trials in the ... Our system addresses these issues, allowing for the dissociation of touch, phasic pain, and tonic pain to better understand their ...