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Mold and bacteria could grow in any brass instrument. And for most players, it wouldn't matter much, except maybe aesthetically. But for a subset of people who react to these organisms, it's no joke.
The sackbut first appeared in the 15th century, and was a prominent brass instrument during the Renaissance, baroque and early classical periods. But by the 18th century, it fell out of use.
Instruments once played by top-shelf brass players, in the CSO and elsewhere, have made their way into Hagstrom, Friedman and Batallán’s collections.