Proinsulin-transferrin (ProINS-Tf) fusion protein was evaluated for its in vivo pharmacokinetics, efficacy, and mechanism. Our previous studies have shown that ProINS-Tf was converted to active ...

Diabetes. 2014;63(5):1779-1788. On the other hand, when mice were administered with equimolar INS or ProINS as ProINS-Tf, BG levels rapidly decreased within the first 2 h and then quickly returned ...

A sentence was incomplete in the 7th point in the legend. The corrected legend appears below. “Orchestrating proinsulin proteostasis in β-cells: Molecular Chaperones, oxidoreductases, and the UPR. (1) ...

proinsulin), brain cortical structure, and cognitive phenotypes (visual memory, reaction time). A bidirectional 2-sample Mendelian randomization (MR) analysis was conducted to examine the influence of ...

Similarly, proinsulin and proinsulin/C-peptide ratios -- measures of beta-cell stress and dysfunction -- dropped with retatrutide by up to 70.5% and 61.6%, respectively, in the type 2 diabetes ...

That’s because in its DNA lies a segment that codes for proinsulin, a protein precursor for the naturally occurring hormone that 8.4 million U.S. citizens need to survive. This has the happy ...

They also evaluated whether the transgenic cow generated through somatic cell nuclear transfer of modified bovine fibroblasts using the lentivirus vector expressed proinsulin in its milk.

Could cow milk be the new cure for diabetes? Researchers have genetically modified a brown cow in Brazil to produce human insulin in its milk, which marks a breakthrough in diabetes treatment ...

To do this, Wheeler and co-authors created a transgenic cow by inserting a segment of human DNA that codes for proinsulin (the protein precursor of insulin) into the nuclei of 10 cow embryos.

From these, they calculated proinsulin to C-peptide (PI:C) ratio. This ratio increases as β cells stop functioning. In the treatment group, PI:C decreased significantly compared with the placebo ...

The research team, led by animal scientist Matt Wheeler from the University of Illinois Urbana-Champaign, inserted a particular segment of human DNA that codes for proinsulin (a protein that's ...

The breakthrough came when the genetically modified cow, after reaching maturity, produced milk containing not just proinsulin but also insulin itself. This development was initially unexpected, as ...