74 As renin has an upstream role in the RAAS cascade, blockade of renin might inhibit the detrimental effects of both angiotensin II and aldosterone, resulting in additive beneficial haemodynamic ...

However, SARS-CoV-2 reduces ACE2 expression, thus leading to lung injury by a cascade of inflammation. ACE inhibitors and ARBs may rebalance the RAAS pathway to favor ACE2 function to oppose the ...