Also, collagen in proximal tubule cells (PTCs) helps maintain the epithelial phenotype of these cells ... tubule physiology with future applications to the study of effects of renal diseases such as ...

The renal tubular epithelial cells (TECs) represent the central cell type ... 1 Origin of proliferating tubule cells. A. The first hypothesis suggests that renal tubular repair originates from a ...

RENTAC targets the kidney via the megalin receptor family—an endogenous cell-surface receptor family expressed at high levels on the apical side of proximal tubule epithelial cells (PTECs ...

The preclinical study showed, for the first time, the investigators claim, that human renal epithelial ... a cell-containing bioreactor component to recapitulate native renal tubule function ...

In terms of clinically applicable prognostic tools, risk stratification using a validated risk model, either the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk model or ...

Xu et al. identified a vicious cycle mediated by leukemia inhibitory factor (LIF)- Sonic Hedgehog (SHH) signaling between fibroblast and tubule epithelial cells. LIF elicits a pro-fibrotic response in ...

Renal cell carcinoma (RCC ... RCC is a disease in which cancer cells develop in the tubules of the kidneys that filter and clean the blood. They remove waste products from the blood and make ...

In kidney morphogenesis, apical-basal polarization of renal epithelial cells is paramount for tubule formation and subsequent tissue functions like excretion and resorption. In kidney epithelium, ...

The pathophysiology of sepsis-AKI involves multiple cell types, including macrophages, vascular endothelial cells (ECs) and renal tubular epithelial cells (TECs ... as well as preventive methods. The ...

These data suggest that proximal tubules, and to a lesser-extent distal tubules ... We also demonstrated for the first time that renal tubular epithelial cells are a major source of IL-18 in this ...