SANTA CLARA, Calif. -- The San Francisco 49ers' 2025 schedule was released along with the rest of the NFL slate Wednesday. The 49ers will open the campaign against the NFC West rival Seattle Seahawks.

Taking a closer look at the San Francisco 49ers 2025 regular season schedule, highlighting must-watch matchups, reacting to the viral schedule release video, and sharing key updates from rookie ...

The San Francisco 49ers are looking for a bounce-back season in 2025. The franchise made major changes in the offseason, most notably bringing back former defensive coordinator Robert Saleh and ...

San Francisco opens the season against Seattle for the third time in series history and for the first time since the 2011 season [W, 33-17 vs. Sea. (9/11/11)]. The 49ers are 23-31 all-time against ...

The San Francisco 49ers are looking to bounce back from a year most fans would prefer to forget. The usually unstoppable offense of Brock Purdy, Christian McCaffrey, Deebo Samuel Sr., Brandon ...

“The San Francisco 49ers could be in the market for Clowney,” Kay said. “There has been a clear need in the Bay Area to assist superstar Nick Bosa in the defensive trenches. The team didn ...

The San Francisco 49ers face a key draft with many roster questions heading into the 2025 season. San Francisco has four picks in the top 100 of the 2025 NFL draft, and there are holes all across ...

Against all odds, the San Francisco Giants won the World Series in 2010, 2012 and 2014. After an off-year that followed a Super Bowl appearance, Brock Purdy and the 49ers wouldn’t mind a similar ...

The San Francisco 49ers have revealed the number of one of their rookies from the 2025 NFL Draft. The 2025 NFL Draft has been completed and teams are beginning to prepare for their upcoming ...

San Francisco 49ers first-round selection, Mykel Williams has officially signed his rookie contract with the team. With the 2025 NFL Draft concluded, this year's draft selections have begun ...

It wouldn't be a San Francisco 49ers offseason without mentions of a trade rumor involving receiver Brandon Aiyuk. The latest comes in rather opportune timing for multiple teams as the 49ers have ...

Check out the full 2025 San Francisco 49ers schedule as well as a record prediction: Eric D. Williams: After having the toughest schedule in the league last year, San Francisco has the easiest ...