The molecular mechanisms of drug induced apoptosis were analysed in wild-type and FADD−/− Jurkat T cells using western blots and caspase assays. Results: While PBL displayed a normal apoptosis pattern ...

This study identifies 53BP1 as an interaction partner of GMCL1 (a likely CUL3 substrate receptor). The study seeks to link this finding to regulation of the mitotic surveillance pathway and paclitaxel ...

MIT researchers found a way to measure cell density quickly and accurately -- measuring up to 30,000 cells in a single hour.

“Among these, we are excited to share updates on ZW209, our DLL3-targeting trispecific T cell engager incorporating co-stimulation, which is on track for IND submission in 1H-2026, and ZW327, our Ly6E ...

Inhibition of beta-cell apoptosis alters the immune environment by reducing pro-inflammatory macrophages and expanding T-regulatory cells ... deoxynucleotidyl transferase dUTP nick end labeling) assay ...

Chimeric antigen receptor (CAR) T cell therapy is a novel cellular therapeutic ... in partnership with ELRIG (UK) Ltd. Multiplexed CAR expression and apoptosis assay can detect the percentage ...

Conclusions Celastrol exerted therapeutic effects on lupus by specifically promoting apoptosis of autoimmune T cells and preventing the progression ... antibody subtypes were measured using the ...

This fundamental study advances our understanding of TRAIL-induced apoptosis by defining how Heparan triggers this pathway at the molecular level. The evidence supporting the conclusions is compelling ...

Using isogenic models of murine T cells with either sufficient or deficient CTLA-4 expression and performing a variety of assays, including cell apoptosis, cell cycle, comet, western blotting, ...

For apoptosis assay, Annexin V-FITC/7-AAD Apoptosis Detection Kit (Sungene, China) was used to detect the apoptotic cells according to instruction Briefly ... groups were performed with independent ...

and these target cells displayed rounding/detachment and cytoplasmic shrinkage, characteristic of progressing through apoptosis. Repeating the assay while using a fixed E:T of 4:1 clearly ...