Consequently, the use-dependent, phasic block (I) is also called hydrophilic while the resting, tonic block (II) is also called lipophilic. The modulated receptor hypothesis assumes altered ...

For the first time, scientists have mapped the 3D structure of the human sweet taste receptor, offering critical insights ...

Yet, despite more than 20 years of study, the sweet receptor’s precise architecture remained elusive, even as scientists ...

It was perhaps not quite how officials, in London at least, had envisaged the announcement of the state visit would be made. In the Oval Office, Donald Trump revealed the news in his own way. "I ...

Pfizer Inc. (NYSE: PFE) today announced the decision to discontinue development of danuglipron (PF-06882961), an oral glucagon-like peptide-1 (GLP-1) receptor agonist, which was being investigated ...

Every soft caress of wind, searing burn and seismic rumble is detected by our skin’s tangle of touch sensors. David Ginty has spent his career cataloging the neurons beneath everyday sensations. Like ...

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are a group of drugs used to treat type 2 diabetes and sometimes obesity. GLP-1 RAs are very effective at lowering blood sugar levels.

2 The Australian Centre for Research into Injury in Sport and its Prevention, Ballarat Federation University, Victoria, Australia Tendinopathy can be resistant to treatment and often recurs, implying ...

Am J Health Syst Pharm. 2009;66(6):541-561. Shorvon et al. [20] conducted a multicenter, double-blind, randomized, placebo-controlled trial to evaluate the efficacy and tolerability of ...

This month’s issue includes: Audio Synthesis for Tonic Textual 🔊 Streamlined access to Ephemeral databases ⏩ Structural support for Kubernetes file mount 🚠 Okta SSO on Structural Cloud and Textual ...