Figure 1: Fringe increases binding of Delta to Notch. Figure 2: Golgi-tethered Fringe increases binding of Delta to Notch. Figure 4: Secreted Notch produced by Fringe–GT-expressing cells binds ...

Digging deeper, the team uncovered the mechanism: HYAL1's breakdown of HA redirects cellular Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), reducing a key modification (O-GlcNAcylation ...

Purpose: The basic concepts of pharmacogenetics, pharmacogenetic study approaches, factors to consider when applying pharmacogenetic discoveries to patient care, and potential roles for ...

Addition of uridine completely and addition of cytidine partially prevented S-D-lactoylglutathione-induced growth inhibition of human leukaemia 60 (HL60) cells in vitro. Other nucleosides had no ...

uridine diphosphate-N-acetylglucosamine; and X5P, xylulose 5-phosphate. Figure 3. Metabolic remodeling and the development of heart failure. Pathological hypertrophy in response to mechanical overload ...

Jiangsu Key Laboratory of Advanced Food Manufacturing Equipment & Technology and State Key Laboratory of Food Science and Technology, School of Food Science and Technology, Jiangnan University, 1800 ...

Objective: The objective of the study was to investigate whether bupropion (BUP) or its circulation metabolites could decrease plasma level of asymmetric dimethylarginine (ADMA) and ameliorate renal ...

Dual antiplatelet therapy with aspirin and an oral P2Y12 inhibitor is indicated for at least 12 months as the default strategy in patients with ACS who are not at high bleeding risk. Several ...

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An International, Prospective, Open-label, Multi-center, Randomized Phase III Study Comparing Lutetium (177Lu) Vipivotide Tetraxetan (AAA617) Versus Observation to Delay Castration or Disease ...