Digging deeper, the team uncovered the mechanism: HYAL1’s breakdown of HA redirects cellular Uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), reducing a key modification (O-GlcNAcylation ...

they discovered that GLUT3-driven glucose absorption activates a metabolic pathway leading to protein modification with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a sugar molecule.

This is a classic example of how a substance may have promising preclinical trials and not pan out. Ginkgo is a bust. Uridine Monophosphate –“a brain energy booster” This can ostensibly improve ...

Introduction: The uridine diphosphate (UDP)-glycosyltransferase (UGT) family is the largest glycosyltransferase family, which is involved in the biosynthesis of natural plant products and response to ...

A recent study published in the journal Nature identified uridine-derived ribose as the fuel for pancreatic ductal adenocarcinoma (PDA) in glucose-restricted conditions. The PDA tumor ...

Figure 1. (L) Glucose, the primary fuel of the body. (R) The chemical structure of uridine diphosphate, an alternate fuel for pancreatic cancer cells. Note that uridine diphosphate contains ribose, ...