The p53 tumor suppressor gene is a sequence-specific transcription factor that activates the expression of genes engaged in promoting growth arrest or cell death in response to genotoxic stress.

We next tested whether IFI 16 and p53 can interact while p53 is bound to DNA. Gel shift assays were performed using double stranded oligonucleotides derived from the p21 waf1/Cip1 promoter ...

An independent validation was performed on 914 patients. Nonmutational p53 dysfunction identifies MDS with poor outcomes that are not efficiently captured by conventional prognostic scores. These ...

A phase I multicenter study to assess the safety, tolerability, and immunogenicity of mRNA-4157 alone in patients with resected solid tumors and in combination with pembrolizumab in patients with ...

Nov. 25, 2021: VHL, VA (SI Sportsbook) is given the 13th sports betting license in VA. Nov. 24, 2021: The Virginia Lottery hands Digital Gaming Corporation (Betway) a temporary sports betting license.

Objective: In this study, our aim was to search for new genotype-phenotype correlations in patients with Von Hippel-Lindau (VHL) disease. This study was approved by the Ethics Committee of the Clinics ...

VHL Technologies (india) Private Limited is an Indian Non-Government Company. It's a private company and is classified as'company limited by shares'. Company's authorized capital stands at Rs 1.0 ...

NTS071 is an oral small molecule allosteric reactivator targeting p53 Y220C with a novel scaffold. It selectively binds to the p53 Y220C mutant protein, improving its thermal stability, thereby ...

Many functions have been assigned to the von Hippel‐Lindau tumor suppressor gene product (pVHL), including targeting the alpha subunits of the heterodimeric transcription factor HIF (hypoxia‐inducible ...

Cohort A1 of LITESPARK-015 trial included patients with advanced PPGL, cohort A2 included patients with pancreatic neuroendocrine tumors (pNETs), cohort B1 included patients with von Hippel-Lindau ...

sund.ku.dk Background Historically, the survival of patients with von Hippel-Lindau disease (vHL) has been poorer than that of the general population. We aimed to determine whether the survival of VHL ...