Interestingly, the same ubiquitin ligase regulates multiple signaling pathways, such as VHL involvement in the HIF signaling pathway, ferroptosis signaling pathway, PI3/AKT signaling pathway, and p53 ...

We thank the members of the W.G.K. laboratory for many helpful discussions and the staff of the Dana–Farber Cancer Institute Animal Resource Facility for the care of research animals that enabled this ...

VHL is a rare genetic disease which puts patients at risk of developing benign blood vessel tumours and several cancers MSD – known as Merck & Co in the US and Canada – has received a US Food and Drug ...

“We think HIF-2 is the driver, or oncoprotein, in VHL–associated renal cell carcinoma cells and, if anything, HIF-1 seems to act as a tumor suppressor and is frequently lost in such tumors,” Kaelin ...

Neddylation is triggered by a cascade of NEDD8-activating enzymes, regulating well known tumor suppressors and oncoproteins, such as VHL, p53, and MDM2 (53). As such, it does not come as a surprise ...

Reovirus infection was able to reduce HIF-1α levels in both von Hippel Lindau (VHL)−/− renal carcinoma A498 and p53−/− HCT116 cells, indicating that the decrease of HIF-1α mediated by ...

In addition, KLF2 maintained its ability to inhibit HIF-1α protein levels in VHL−/− cells, thermo-sensitive E1 deficient cells, and p53−/− cells. Finally, co-immunoprecipitation experiments revealed ...

Using combined pharmacological, biochemical and genetic approaches, we show here that HDAIs repress the transactivation potential of both HIF-1aCAD and HIF-2aCAD independent of the tumor suppressors ...

VHL/E-infected HAECs (day 9) were stained with anti-IE antibody-FITC (green), anti-Bak antibody-Texas Red (red), and DAPI (blue). Merged image shows colocalization. Activation of the p53 Pathway in ...