University of California, Los Angeles and University of California, San Diego researchers developed an injectable sealant for ...

Conversely, in tumor contexts where AIM2 exerts oncogenic effects, it fosters an immunosuppressive environment marked by M2 macrophage polarization and upregulation of PD-L1, thereby dampening the ...

cHL presents a bimodal age distribution, with distinct TME characteristics across age groups: Left: cHL age in pediatric patients age <10y: The TME is enriched with M1 macrophages, accompanied by a ...

On the one hand, macrophages can phagocytose degradation products and form ... were prepared and incubated overnight at 4 °C with commercially available antibodies, including CD68 (Abcam, USA), P2X7 ...

Although the study did not meet its primary end point, correlative analysis demonstrated that four of the five long-term survivors had an immune-rich pretreatment TME, three of whom had a reduction in ...

The parasite causing cutaneous leishmaniasis infects macrophages, so the CD68 myeloid marker can be used to identify myeloid cells in skin tissue. The study found that infected macrophages express ...

Given the contribution of EC-derived EVs to atherosclerosis, this model represents the first in vivo murine approach to tracking intercellular EC-EV communication within the plaque. It provides an ...