Despite PINK1’s recognized importance in Parkinson’s disease, studying this elusive protein has frustrated researchers for years.

WEHI researchers have made a huge leap forward in the fight against Parkinson’s disease, solving a decades-long mystery that paves the way for development of new drugs to treat the condition.. First ...

In this way, PINK1 has been known to play an important role in the early onset of Parkinson's disease, and scientists have been able to capture differing images of they way it is activated.

A form of Parkinson’s disease caused by mutations in a gene known as PINK1 has long been labelled rare. But our research shows it’s anything but – at least for some populations. Our meta-analysis ...

Mutations in the gene that codes for PINK1 cause a common form of Parkinson disease. Here the authors show that PINK1 phosphorylates TRAP1, which suppresses apoptotic release of cytochrome c from ...

In Parkinson’s disease, mutations in PINK1 and Parkin can result in the accumulation of damaged mitochondria in the brain, leading to the tremors and stiffness that are the hallmarks of the ...

Researchers have zeroed in on a mechanism that may promote the earliest stages of mitochondrial decline in Parkinson’s disease (PD). Mutations that hinder the kinase activity of the ...

A new study reveals that T cells mistakenly attack brain cells expressing PINK1, contributing to Parkinson’s disease. The research also highlights a striking sex difference, with men showing a sixfold ...

In particular, PINK1 has been linked to young-onset Parkinson’s Disease, which affects people under the age of 50. Despite the known link, researchers have previously been unable to visualise ...

PINK1 protein discovery could accelerate Parkinsons disease drug development New insights into mitochondria may pave the way for innovative treatments in neurodegenerative disorders.

Mitokinin is developing a PINK1-activating therapeutic compound that is designed to address mitochondrial dysfunction believed to be a major contributing factor to Parkinson's disease pathogenesis ...