Impact of BRCA alterations on androgen receptor pathway inhibition treatment outcome in advanced prostate cancer.. JCO 43 , e17074-e17074 (2025). DOI: 10.1200/JCO.2025.43.16_suppl.e17074 ...

A first-in-human, phase 1 dose escalation and expansion study evaluating the safety, tolerability, and anti-tumor activity of [225Ac]Ac-FL-020, an anti-PSMA radioconjugate, in patients with metastatic ...

Smad7 controls inflammation by negatively regulating activation of the transcription factor NF-κB. New work shows that Smad7 inhibits NF-κB by binding to the regulatory proteins TAB2 and TAB3 ...

Armed with base editors, scientists from the laboratory of David Liu, PhD, professor and director of the Merkin Institute of Transformative Technologies in Healthcare at the Broad Institute, and ...

The goal here is to mediate the IL-1/Toll-Like Receptor [TLR] pathways by degrading IRAK4. Lastly, it is waning to get another protein degrader into the clinic in the early part of next year.

You can think about stat six, for example, that is a undrugged transcription factor in a highly validated pathway like the IL-four and IL-thirteen that has never again, as I said, never been drugged ...

We discovered a negative regulator for IL-1R-TLR signaling, the single immunoglobulin IL-1 receptor-related molecule (SIGIRR). We continue to investigate the detailed molecular mechanisms by which ...

Approach to selecting among multiple androgen receptor pathway inhibitors; Individualization of therapy based on patient factors; Consideration of drug-specific characteristics; Expert Insights: Dr ...

The toll‐like receptor (TLR) signaling pathway is the front‐line subsystem against invasive microorganisms for both innate and adaptive immunity (Iwasaki and Medzhitov, 2004).To sense innumerable and ...