Insights on preventing organ transplant rejection Study identifies receptors that slow inflammation, signaling a promising target for new therapies Date: May 7, 2025 Source: Mass General Brigham ...

Let us delve into some of the TLR agonists in the clinic and why the careful selection of these drugs is crucial.

Tenaya Therapeutics announces interim data from the RIDGE study on PKP2-associated ARVC, exploring gene therapy potential.

A phase 1b/2 study evaluating the activity of tinengotinib in combination with androgen receptor pathway inhibitors (ARPIs) in patients with metastatic castration resistant prostate cancer (mCRPC).

Label-free biosensor assay detects Toll-like receptor signals and even discriminates between different signaling pathways.

Toll-like receptors (TLRs) are a class of pattern recognition receptors (PRRs) crucial for the detection of infections and activation of downstream signaling pathways that lead to the production of ...

AAV9, for one, crosses the BBB and is commonly used for CNS therapies, such as the FDA-approved spinal muscular atrophy treatment Zolgensma (Nov 2019 conference news). Deverman and colleagues thought ...

The team said that the new AAVs are ideal for gene therapy because they target a human protein and have similar production and purification yields as AAV9 using scalable manufacturing methods.

In an important step toward more effective gene therapies for brain diseases, researchers from the Broad Institute of MIT and Harvard have engineered a gene-delivery vehicle that uses a human ...

The IL-17 pathway exhibits diverse functions between animal subphyla, classes, and even orders, yet what drives this remains elusive. Here, we demonstrate that this pathway originated at the dawn of ...

Ring Therapeutics, a life sciences company founded by Flagship Pioneering to revolutionize programmable medicines with its commensal virome platform, today announced a pre-print publication in bioRxiv ...