We examined the changes of expression and function of the toll-like receptor 9 (TLR9) signal transduction pathway in the peripheral lymphocytes with different treatment methods and investigated the ...

Objective Recent evidence suggesting an important role of gut-derived inflammation in brain disorders has opened up new directions to explore the possible role of the gut-brain axis in ...

The toll‐like receptor (TLR) signaling pathway is the front‐line subsystem against invasive microorganisms for both innate and adaptive immunity (Iwasaki and Medzhitov, 2004).To sense innumerable and ...

The divergent synthesis of nitrogen-containing multicyclic scaffolds with quaternary carbon centers at ring junctions remains a major challenge. This study has developed a versatile and programmable ...

Anthropogenic pollutants can greatly mediate formation pathways and chemical compositions of secondary organic aerosol (SOA) in urban atmospheres. We investigated the molecular tracers for different ...

The potential therapeutic role of the HMGB1-TLR pathway in epilepsy. Curr Drug Targets. (2021) 22:171–82. PubMed Abstract | Google Scholar. 42. Li XL, Wang S, Tang CY, Ma HW, Cheng ZZ, Zhao M, et al.

Recent studies provided evidence that phosphatidylinositol 3-kinase (PI-3K) is implicated in macrophage proliferation induced by oxLDL. 5 PI-3K is activated by growth factors and peptide hormones ...

These genes are primarily involved in immune-related pathways, including Toll-like receptor (TLR) signaling, and interact with MS therapeutics such as teriflunomide. Among the identified DEcircRNAs, ...

The goal here is to mediate the IL-1/Toll-Like Receptor [TLR] pathways by degrading IRAK4. Lastly, it is waning to get another protein degrader into the clinic in the early part of next year.

Impact of BRCA alterations on androgen receptor pathway inhibition treatment outcome in advanced prostate cancer.. JCO 43 , e17074-e17074 (2025). DOI: 10.1200/JCO.2025.43.16_suppl.e17074 ...