This region is called the ''Fc (Fragment, crystallizable) region''. In this area are two heavy chains that contribute two or three constant domains depending on the class of the antibody.

In a Nature Communications paper, the laboratory of Professor Jan Terje Andersen and collaborators report on a novel antibody constant region (Fc) variant that is designed to give antibodies broad ...

The first generation of humanized antibodies - referred to as chimeric antibodies - saw the constant regions of a mouse antibody replaced with those of a human antibody, considerably reducing ...

The scaffold has been developed by incorporating specific amino acid changes in the CH3 region of the constant Fc domain of a native IgG1 class antibody. Zymeworks claims that in addition to ...

Researchers have devised a new way to sneak therapeutic cargo across the blood-brain barrier. Into the constant region of a human IgG1 antibody, they slid a domain that latches onto receptors that ...