When scientists engineer a better way to fight the flu, they often begin with nature’s own defenses. That’s what a new study ...

Royalty-free licenses let you pay once to use copyrighted images and video clips in personal and commercial projects on an ongoing basis without requiring additional payments each time you use that ...

But even novel antibody sequences may face obviousness rejections if complementarity-determining regions (CDRs ... 1×10−10M or less and a koff rate constant of 1×10−3 s−1 or less, as ...

Here we present the first study to investigate the effect of removing the constant regions from antibodies and T-cell receptors on such simulations. We performed simulations of an antibody/antigen and ...

This suggests an absence of ‘inactive-active’ conformational states in the TCR constant regions and the extracellular CD3 subunits ... These blots were stained with anti-TCRα (cMyc) antibody and ...

highly varied BCR/antibody repertoire. 9 Each immunoglobulin results from the pairing of 2 heavy chains (μ, δ, γ, α, or ε) with 2 light chains (κ or λ), each consisting of a constant and a variable (V ...

The patent covers variations of the antibody, including chimeric, humanized, and caninized forms, with constant regions derived from human or canine IgG1 antibodies. Moreover, the patent includes ...

WuXi Biologics Cayman has been granted a patent for a polypeptide complex that combines antibody variable regions with TCR constant regions. The complex can be used in treating diseases and disorders.

In a Nature Communications paper, the laboratory of Professor Jan Terje Andersen and collaborators report on a novel antibody constant region (Fc) variant that is designed to give antibodies broad ...

Elanco Animal Health research scientists developed CPMA in several steps. The antibody was encoded with DNA using a dog constant region and a rat variable region to create a chimeric antibody composed ...

NeoMab™ is developed on the widely recognized BALB/c genetic background, rendering it highly suitable for industry-leading antibody discovery. This model retains the native mouse constant region ...