Abs make up one of the most important classes of advanced biotherapies. GEN interviewed leaders about current challenges and advances.

Antisperm Antibody An ASA is defined as an immunoglobulin with antibody activity against a sperm antigen that plays a role in fertility, since not every antibody that binds to the sperm surface ...

The highly virulent and transmissible SARS-CoV-2 causes COVID-19 and poses a global public health threat. Herein cloned, expressed, and the molecular weight of the receptor-binding domain (RBD) of the ...

We test AlphaRED’s docking accuracy on a curated set of benchmark targets of bound and unbound protein structures of varying levels of binding-induced conformational change, including antibody–antigen ...

How have nanobodies evolved since their discovery? Nanobodies were first identified in the early 1990s. The breakthrough came in 1993 with the discovery of heavy-chain-only antibodies in camels, which ...

VUMC has been awarded up to $30 million from the Advanced Research Projects Agency for Health (ARPA-H) to build a massive antibody-antigen atlas, develop AI-based algorithms to engineer antigen ...

With flexible antibody formats such as 1×1, 2×1, and 2×2 for expanded targeting, it is ideal for creating novel bispecific therapeutics for intravenous and subcutaneous administration. Figure 2.