B lymphocytes exhibit dual roles in tumorigenesis, acting as both allies and adversaries in the tumor microenvironment (TME).

Researchers show that analyzing the 3D shapes of antibodies, not just their genetic sequences, can better group functionally ...

Fine-tuned by the immune system to latch onto a particular site on a pathogen ... multiple factors could be at play, including binding location. Antibodies that target the same viral protein ...

We selected a streptavidin-coated 96-well plate to evaluate the antigen-binding capacity of the randomly and site-specifically biotinylated antibodies. This is a commercially available solid-phase ...

Monoclonal antibody (mAb) therapy is based on the concept that ... On the other hand, experience with these and other less successful mAbs has demonstrated that binding of a mAb to target antigen on a ...

such as antigens or immunogens. That binding process depends on many factors. “One often overlooked parameter is the exact binding site of your antibody on the protein of interest, also known as ...

These are proteins that bind to specific antigens on target cells, such as bacteria. Monoclonal antibodies work similarly, binding only to specific antigens. This can help the body fight disease.

The exceptional specificity of how antibodies and antigens interact forms the foundation of the reliability and precision of ELISA tests. Antibodies, which are proteins generated by our immune system ...

Each of these modified antibodies still maintained trastuzumab-specific binding to cells expressing the HER2 antigen, the target of trastuzumab ... that would allow release of the cargo at that site.

the C-terminal fusion of a pair of weakly homodimerizing proteins to three different antibodies enhanced the antigen-binding avidity by at least 110 or 304 folds from the intrinsic binding avidity.