Here the authors train multivariate logistic regression models on over 52,000 MTBC isolates to associate binary resistance phenotypes for 15 antitubercular drugs with variants extracted from ...

Researchers propose that the so-called Mediterranean diet is of particular benefit to mental health. One study notes that, “Such diets are characterised by the high intake of vegetables, fruit, whole ...

Within this context, new therapeutic alternatives are needed, if possible, acting via innovative mechanisms to overcome concerns of resistance to clinically available drugs. An example of this ...

Effective cancer therapeutics for brain tumors must be able to cross the blood-brain barrier (BBB) to reach the tumor in adequate quantities and overcome the resistance conferred by the local tumor ...

Tuberculosis (TB) is caused by the slow-growing acid-fast bacillus Mycobacterium tuberculosis. Until 1980 it was considered as a controlled disease worldwide; however, this scenario was transformed ...

In this important study, the authors investigate the biogenesis of extracellular vesicles in mycobacteria and provide several observations to link VirR with vesiculogenesis, peptidoglycan metabolism, ...

μ-VIS X-Ray Imaging Centre, Faculty of Engineering and Physical Sciences, University of Southampton, Southampton SO17 1BJ, U.K. Institute for Life Sciences, University of Southampton, University Road, ...

This important study investigates the localization dynamics of the mycobacterial mutasome complex, comprised of ImuA', ImuB, and DnaE2. The mutasome complex has a key role in promoting mutagenic DNA ...

Quinoline is one of the most common nitrogen-containing heterocycles owing to its fascinating pharmacological properties and synthetic value in organic and pharmaceutical chemistry. Functionalization ...