NFL regular season schedule has been released and per NFL research, Buffalo shares the ninth-easiest schedule with Jacksonville. Here's what stands out from the slate.

The NFL officially released its full slate of games for the 2025 season on Wednesday. The schedule is full of intrigue as the Bills look to build toward their sixth-consecutive AFC East crown. However, Buffalo will face off against multiple teams that have ended their season in recent years.

Buffalo Bills play their lone preseason game on the 2025 NFL schedule. The Bills will welcome back to Orchard Park for the 1 p.m. kickoff former offensive coordinator Brian Daboll and former assistant GM Joe Schoen who are bringing their re-tooled New York Giants to town which includes former Bills running back Devin Singletary.