The appearance of glial scars around the lesion site and the release of axon growth inhibition factor are key events affecting spinal cord regeneration. At present, few studies have focused on the ...

The bioprinted spinal cords also decrease the glial scar while increasing regenerative axons. Although spontaneous tissue regeneration is limited in the CNS, tissue engineering strategies to overcome ...

Hand2 gene is expressed only on the posterior limb side, maintaining positional memory that directs regeneration. Upon injury, increased Hand2 activates Shh signaling, which patterns the regenerating ...

Stathmin-2 is a neuron-specific protein essential for the maintenance of axonal health and muscle innervation, whose normal expression is lost in many neurodegenerative diseases. Its expression is ...

Department of Neurosurgery General, the First Medical Centre, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, P. R. China Beijing Key Lab of Regenerative Medicine in Orthopedics; Key ...

Stable alterations of this kind are said to be 'epigenetic', because they are heritable in the short term but do not involve mutations of the DNA itself. Research over the past few years has ...