Biological cells often possess thin, hair-like protrusions on their surface known as cilia, which serve various functions ranging from movement to sensing environmental signals. Researchers from ...

By reexamining 3D images used to map the connections between brain cells, researchers are uncovering new information about a small, elusive, and often overlooked cellular appendage.

Strikingly, the researchers also observed similar cilia defects in motor neurons from ALS patients with mutations in one of the most common genetic causes of ALS, C9orf72.

The Walton et al paper shows human CCDC96/113 in cilia of human respiratory epithelia. An application of such methodology to the proteins indicated by Wu et al for the sperm axoneme and head-tail ...

Using the marker GT335, we saw the cilia in TTLL12 KO cells do have glutamylated tubulin, similar to WT cells (Fig. 4B), suggesting TTLL12 is not required for intracellular ciliogenesis but is ...

The axoneme is very flexible, meaning micrometre-scale waves can travel along it. It is the active core of the flagellum and is responsible for propelling sperm cells along. They can even sense ...

In addition to human cilia, the team examined the axoneme structure of a single-celled alga called Chlamydomonas reinhardtii, which uses two tail-like projections on its surface to swim.

In addition to human cilia, the team examined the axoneme structure of a single-celled alga called Chlamydomonas reinhardtii, which uses two tail-like projections on its surface to swim.

For the first time, the scientists visualised the molecular ‘nano-machinery’ that causes cilia to beat, visible as identical structures dotted every 96 nanometres along the cilia length. These ...

The axoneme has a characteristic nine-doublet outer ring of microtubules, with no central microtubule at the base; however, this structure may change after cilia emerge from the cell surface.