Talin is a protein that plays an important role in the immune system by activating integrins, receptors that help cells ...

B-cell acute lymphoblastic leukemia (B-ALL) is the most common cancer in children, accounting for around 85% of pediatric ...

Researchers at the University of Michigan designed an optimized viral protein able to boost the antitumor function of T cells. The project stemmed from observations on the particular system employed ...

ABOUT CARVYKTI® (CILTACABTAGENE AUTOLEUCEL; CILTA-CEL) ...

MessageGears, the leading data activation and engagement platform for enterprise brands, today announced it has been recognized as a Validated Partner of Databricks, the data and AI company. The ...

The EC has granted conditional marketing approval to Regeneron Pharmaceuticals’ bispecific antibody Lynozyfic for treating multiple myeloma.

The “off-the-shelf” CAR T-cell therapy CTD402 will be evaluated in a phase 1b/2 trial for patients with T-cell acute lymphoblastic leukemia and lymphoma. The FDA has cleared an investigational new ...

Cytotoxic or CD8 + T-cells, known for their ability to kill infected and cancer cells, require activation and differentiation within specialized niches of the tumor microenvironment to effectively ...

and LAG-3), increased expression of activation markers (eg, CD38 and CD25), and reduced expression of cytotoxic activity markers (eg, granzyme B). 18,51,54 Reflecting better T-cell fitness, patients ...

can result in targeted clearance of CD38-positive cells, including plasma cells. We conducted a phase 1–2, open-label study to evaluate the safety and efficacy of CM313 in adult patients with ITP.

T cell activation, a process requiring three “signals,” is required for optimal anti-tumor immunity. T cells, immune cells generated in the thymus, have a programmed affinity for a specific particle ...