With a few exceptions, eukaryotic chromosomes have a single centromere that ensures their accurate segregation during mitosis. Chromosomes that lack centromeres segregate randomly during mitosis ...

These kinetochores are responsible for the attachment of spindle microtubules, which enable chromosome congression and proper segregation during cell division. Defects in the structure or function ...

During chromosome segregation, the kinetochore serves as an attachment point for microtubules, which exert strong forces as they winch the chromosomes apart. In human cells, a protein complex ...

We present a new physical biology approach to understanding the relationship between the organization and segregation of bacterial chromosomes. We posit that replicated Escherichia coli daughter ...

Mistakes in chromosome segregation can lead to cell death and cancer development. The researchers discovered that the centromere consists of two subdomains. This fundamental finding has important ...

Chromosome segregation happens after fertilization when the zygote begins to go through cell division. When the cell divides, both cells should have a complete set of chromosomes. When this does ...

We usually think of the chromosome segregation machinery as ensuring unbiased, random segregation. As we learn in high school biology, if a diploid individual carries two different alleles of a gene ...

My research focuses on the segregation of chromosomes during cell division. Chromosomes are the bodies that contain our DNA and it’s critical that each cell has the correct DNA in the correct quantity ...

Aneuploidy and its consequences on the cell Aneuploidy, a state where cells have an incorrect number of chromosomes, is ...

Unlike cancer cells, normal cells do not tolerate errors in chromosome segregation. This finding, which we published in Nature in 2018, suggested that the act of being unstable is itself critically ...

Mistakes in chromosome segregation can lead to cell death and cancer development. The researchers discovered that the centromere consists of two subdomains. This fundamental finding has important ...

In addition, the presence of supernumerary chromosomes in men can disrupt normal chromosome segregation during sperm production, which can cause infertility. The scientists discovered the dynamics ...