These kinetochores are responsible for the attachment of spindle microtubules, which enable chromosome congression and proper segregation during cell division. Defects in the structure or function ...

We present a new physical biology approach to understanding the relationship between the organization and segregation of bacterial chromosomes. We posit that replicated Escherichia coli daughter ...

Aneuploidy and its consequences on the cell Aneuploidy, a state where cells have an incorrect number of chromosomes, is ...

Mistakes in chromosome segregation can lead to cell death and cancer development. The researchers discovered that the centromere consists of two subdomains. This fundamental finding has important ...

We usually think of the chromosome segregation machinery as ensuring unbiased, random segregation. As we learn in high school biology, if a diploid individual carries two different alleles of a gene ...

Chromosome segregation happens after fertilization when the zygote begins to go through cell division. When the cell divides, both cells should have a complete set of chromosomes. When this does ...

Mistakes in chromosome segregation can lead to cell death and cancer development. The researchers discovered that the centromere consists of two subdomains. This fundamental finding has important ...

Meiosis reduces ploidy by following one round of DNA replication with two rounds of chromosome segregation (Meiosis I and Meiosis II respectively). In Meiosis I homologous chromosomes separate, which ...

Unlike cancer cells, normal cells do not tolerate errors in chromosome segregation. This finding, which we published in Nature in 2018, suggested that the act of being unstable is itself critically ...

The microtubules making up the mitotic spindle are shown in green. Timelapse of chromosome segregation in a larger fish embryo Close-up timelapse of chromosome segregation in an early fish embryo ...

In addition, the presence of supernumerary chromosomes in men can disrupt normal chromosome segregation during sperm production, which can cause infertility. The scientists discovered the dynamics ...

alters gene expression linking increased germline oxidative stress with compromised genomic integrity and errors in meiotic chromosome segregation." More information: Henderson AL, Karthikraj R ...