Scientists have discovered a previously unrecognized way that human airways protect lungs from infection—through the action of cilia, tiny hair-like structures lining the respiratory tract.

Early fallopian tube cell changes were found in a high‑risk patient. A live tissue bank and organoid system will help explore initial ovarian cancer development. Very little is currently understood ...

Ciliary epithelial proliferation was seen in most cases with increasing time following treatment, in a disorganised pattern, without replication of the ciliary epithelial bilayer. No regeneration of ...

AIMS To define a retinoinvasive phenotype of uveal melanoma based on an informative case and survey of literature. METHODS A 65-year-old woman developed a circumscribed mixed cell type melanoma of the ...

The work in my group involves developing optimal methods for delivery of CRISPR/Cas9 formulations, developing air-liquid interface models of the CF epithelium for identifying biological readouts and ...

Primary ciliary dyskinesia (PCD) is a genetic disease caused by mutations in genes affecting the structure and movement of the cilia lining the upper airways. Aims/Objectives: We aim to develop mRNA ...

Cilia are outgrowths of the plasma membrane of eukaryotic cells that contain a specialised cytoskeleton. Motile cilia are present on multiciliated cells and use this cytoskeleton to move fluid ...

This study identifies astrocyte-intrinsic mechanisms by which the LRRK2 G2019S, a mutation linked to familial Parkinson's disease, disrupts synaptic integrity in the anterior cingulate cortex. The ...

Epithelial cellular adhesion molecules (EpCAM), highly expressed antigens on cancer cell surfaces, are crucial biomarkers for tumor diagnosis and therapy. Despite its utility, the efficiency of ...

The authors further stated that the organoid culture system could serve as a model to explore the intestinal epithelium of patients with IBD. We hereby provide new support that intestinal organoid ...