sBT of 20 ug/L or higher is one of the minor criteria for systemic mastocytosis and typically increases the suspicion that a patient could have a primary clonal mast cell disorder. Of note, though ...

If the person meets the criteria for a diagnosis of MCAS, a doctor needs to rule out a primary clonal mast cell disorder as the cause. This requires further blood testing for a mutation called KIT ...

“Separately or in association, these 2 tests can help identify mast cell involvement in disease, confirm diagnosis ... presenting with mast cell-driven diseases, from allergy to clonal mast cell ...

Systemic mastocytosis (SM) is a rare disease driven by the KIT D816V mutation in about 95 percent of cases. Uncontrolled proliferation and activation of mast cells result in chronic, severe and ...

underscoring the importance of treating patients early in the ISM disease course -- -- BLU-808 healthy volunteer trial results demonstrate wide therapeutic window for modulating mast cell activity ...

Introduction: The clinical significance of elevated baseline serum tryptase (BST) in the absence of mast cell disorders or allergic reactions ... but higher rates of chronic kidney disease (12.1%) and ...

Inappropriate activation of mast cells — now termed mast cell activation disease (MCAD) — has long been known to underlie allergic symptoms and inflammation, and far less commonly, neoplasias ...

Q: My doctor thinks my mast cells are activating inappropriately and may be causing many of the symptoms I periodically have. Please tell me more about this condition. A: Mast cells are an ...

2018.77605 The Mast Cell Disease Society. Medications to treat mast cell diseases. González-de-Olano D, Matito A, Orfao A, Escribano L. Advances in the understanding and clinical management of ...

In a series of Instagram posts, Halsey shared that they were diagnosed with lupus and a T-cell lymphoproliferative disorder. A T-cell lymphoproliferative disorder is an umbrella term for a host of ...