Study examines how compound damaged DNA to understand its connection to cancer Date: February 14, 2019 Source: Harvard University Summary: In an effort to understand how colibactin, a compound ...

The new compound effectively bound to plasmid DNA without affecting its structure. Injected into mouse muscles, the team observed widespread gene expression, promising applications to treatments ...

Drug discovery efforts based on DNA-encoded chemical libraries are inadvertently overlooking numerous potential drug ...

DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. Its function is based on two catalytic steps: firstly, it cuts and then relinks the DNA, thus relaxing ...

For example, a compound found in cigarette and industrial smoke, benzo(a)pyrene (BaP), is known to damage DNA. Now, researchers reporting in ACS Central Science have mapped these effects — down to the ...