Within 24 hours of hospitalization, participants were randomly assigned to dapagliflozin 10 mg once daily or structured usual care with protocolized diuretic titration until day 5 or hospital ...

Dapagliflozin, an investigational compound, is a potential first-in-class sodium-glucose cotransporter-2 (SGLT2) inhibitor currently in Phase 3 trials under joint development by Bristol-Myers ...

After 24 weeks, individuals receiving dapagliflozin 2.5 mg, 5 mg and 10 mg plus metformin demonstrated ... currently being evaluated in Phase 3 trials as a once-daily oral therapy for the ...

Patients were randomized (1:1:1) to oral dapagliflozin 5 mg or 10 mg once daily or matched placebo, plus insulin. For safety analyses, 833 patients were randomized to groups (dapagliflozin 5 mg n ...

the 271 patients assigned to dapagliflozin 5 mg daily achieved a 0.37% decline in HbA1c; the 270 patients assigned to dapagliflozin 10 mg daily achieved a 0.42% decline in HbA1c; the 272 patients ...

After this screening, patients were randomly assigned to receive either dapagliflozin (at a dose of 10 mg once daily) or matching placebo, in accordance with the sequestered, fixed-randomization ...

In the ROTATE-3 crossover trial, investigators randomly assigned 46 patients to 3 consecutive 4-week treatments of dapagliflozin 10 mg once daily, eplerenone 50 mg once daily, or a combination of ...

Within 24 hours of hospital presentation, patients were randomly assigned in a 1:1 ratio to oral dapagliflozin 10 mg once daily or structured usual care until day 5 or hospital discharge.

Trial investigators randomized 6,263 patients with an LVEF over 40%, evidence of structural heart disease, and elevated natriuretic peptides to dapagliflozin 10 mg once daily or placebo on top of ...

ORLANDO, Florida — The sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin (Jardiance) significantly slowed progression of renal dysfunction or death from cardiovascular causes among ...

once-daily dose as follows for 24 weeks: Morning dose: placebo (n=75), dapagliflozin 2.5 mg (n=65), dapagliflozin 5 mg (n=64) or dapagliflozin 10 mg (n=70); Evening dose: dapagliflozin 2.5 mg (n ...