Kendrick Perkins is backing Tom Thibodeau. The New York Knicks fired Thibodeau on Tuesday following a season in which they made the Eastern Conference finals for the first time in 25 years. They ...

In this paper, a chemically-consistent reaction mechanism is proposed for the demethylation of histone tail lysine residues and the reaction path analysis of this mechanism is carried out. Potential ...

DNA demethylation during spermatogenesis presets the sites of nucleosome retention in spermatozoa During spermatogenesis, histones are largely replaced with protamines. In spermatozoa, nucleosomes are ...

The reaction volume was adjusted with reaction buffer to obtain final oligonucleotide and protein concentrations: 10 μM 60‐mer homoduplex G•C‐ or G•5caC‐containing oligonucleotide, 2 μM TDG, 5 nM ...

Reversing this modification requires DNA demethylation, a series of enzymatic reactions which starts with the creation of 5-hydroxymethylcytosine (5hmC).

Demethylation of H3K27 Is Essential for the Induction of Direct Cardiac Reprogramming by miR Combo. Sophie Dal-Pra, Conrad P. Hodgkinson, Maria Mirotsou, ... showed decreased H3K27me3 as revealed by ...

SALL4 up-regulation after treatment with hypomethylating agents was observed in 10 of 25 patients (40%) in cohort 1 and in 13 of 43 patients (30%) in cohort 2 and was associated with a worse ...

In summary, our study suggests that impaired demethylation in the transition from naïve to memory B cells in CpGs at genes implicated in B cell signaling and survival (STAT3, AKT1, FOXO, and NFKB2), ...

The C-4 demethylation reaction is completed by reduction of the C-3 ketone to yield the final sterol product, 4-desmethyllanosterol (IV). Many NAD(P)-dependent ketosteroid reductases also catalyze the ...